Category: lung

Living Longer: Stage 4 Lung Adenocarcinoma EGFR Mutation positive

Living Longer: Stage 4 Lung Adenocarcinoma EGFR Mutation positive

Introduction Firstly, with optimal palliative chemotherapy treatment for stage 4 lung cancer, the average survival is slightly under a year; 7.4 months - 8.1 months (Schiller JH, 2002), which doubled the average survival with just best supportive care, 3.9 months. Although improvement in survival was achieved with chemotherapy, it seemed like chemotherapy alone had reached … Continue reading Living Longer: Stage 4 Lung Adenocarcinoma EGFR Mutation positive

Better Practice: Improving first-line treatment against Stage 4 ALK-positive non-small cell lung cancer (NSCLC)

Introduction For patients with stage 4 lung adenocarcinoma, they should be tested for anaplastic lymphoma kinase (ALK) fusion oncogene rearrangements, which affects about 5% of non-small cell lung cancer (NSCLC). This group of stage 4 lung cancer is highly sensitive to ALK inhibitors (crizotinib, ceritinib, alectinib, brigatinib, ensartinib and lorlatinib). Crizotinib The first ALK inhibitor … Continue reading Better Practice: Improving first-line treatment against Stage 4 ALK-positive non-small cell lung cancer (NSCLC)

Better Practice: Trimodality Treatment, 3x Improvement in Stage 3 Non Small Cell Lung Cancer (NSCLC)

Better Practice: Trimodality Treatment, 3x Improvement in Stage 3 Non Small Cell Lung Cancer (NSCLC)

Introduction Every year, there will be a certain treatment that will be the highlight of discussion and presentations in every oncology meetings/ events. Last year, it was immunotherapy durvalumab, which delivered superior results for stage 3 non-small cell lung cancer (NSCLC); adenocarcinoma and squamous irrespective of EGFR status (wild type or mutant) irrespective of PD-L1 … Continue reading Better Practice: Trimodality Treatment, 3x Improvement in Stage 3 Non Small Cell Lung Cancer (NSCLC)

Lung Cancer: Clinical Research Data vs. Real World Data. Comparable?

Lung Cancer: Clinical Research Data vs. Real World Data. Comparable?

In a conversation with my colleague, I was telling him that it would be nice to have more real world practice data. It would be interesting to see if results from real world practice is similar (or not) to those reported in clinical trials, which are conducted and tightly monitored for treatment effectiveness and patient … Continue reading Lung Cancer: Clinical Research Data vs. Real World Data. Comparable?

Stage 4 Lung Cancer: How Long Can I Live? (2)

Stage 4 Lung Cancer: How Long Can I Live? (2)

I saw a patient today with stage 4 lung cancer. He told me he has another 4-6 months to live, according to his doctor. Is it true? No Nowadays, it is not just 'stage 4' determining the survival time. Let me elaborate. I will try to keep it simple. Histology First, there is the histology … Continue reading Stage 4 Lung Cancer: How Long Can I Live? (2)