Another Good News for Breast Cancer Patients (with ER positive, HER2 negative)

In advanced breast cancer, two criteria when deciding suitability for hormonal therapy are: Estrogen receptor (ER) positive and HER2 negative NOT in visceral crisis Visceral crisis is defined as severe organ dysfunction as assessed by signs and symptoms, laboratory studies and rapid progression of disease. Visceral crisis is not the mere presence of visceral metastases …

Early Breast Cancer: Importance of Hormonal Therapy in ER-positive Breast Cancer

A young lady in her early 40s had left breast cancer, pT2N2MO (stage III), ER positive, HER2 negative. She completed surgery, chemotherapy and radiotherapy. When I told her that she will need hormonal therapy for up to 10 years based on latest study, she said the study must be pharma-sponsored to encourage longer use of …

Living Longer: Advanced Breast Cancer (ABC) – Hormone positive; ER (+ve), HER2 (-ve)

Introduction In patients with advanced breast cancer AND ER positive AND HER2 negative AND no presence/ impending visceral crisis, the recommended treatment by various international guidelines is hormonal therapy. Chemotherapy is only for rapidly progressive disease OR in the setting of visceral crisis OR no more response from available hormonal therapy. HER2 directed treatment is applicable …